Nancy Maizels, PhD
NGEC Principal Investigator
Professor of Immunology and Biochemistry
Director, Molecular Medicine Program
Department of Immunology
University of Washington
1959 NE Pacific St.
HSB, H479, Box 357650
Seattle, WA 98195-7650
Tel: 206-221-6876; Fax: -206-221-6781
Dr. Maizels is a professor of immunology and biochemistry at the University of Washington. Dr. Maizels's research focuses on mechanisms of genomic instability in mammalian cells, particularly activated B cells, and she is internationally recognized for her work on mechanisms of mutagenesis and recombination. Her laboratory has ongoing work on the basic mechanisms of DNA repair and somatic hypermutation, the application of somatic hypermutation as a tool for in vitro antibody engineering and manipulation of repair mechanisms to enhance recombination at nuclease-induced double strand breaks.
Dr. Maizels is the NGEC principal investigator in the area of targeted gene repair by homologous recombination.
Areas of Expertise
- Immune response
- DNA repair
- Mechanisms of immunoglobulin gene diversification
- Genomic instability
- Homology-directed gene correction
Overview of the Maizels Lab
The Maizels Laboratory studies mechanisms of immunoglobulin gene diversification, genomic instability and homology-directed gene correction. The lab has made significant recent advances by defining the essential steps in the molecular mechanism of immunoglobulin gene diversification, and by identifying novel structures form in G-rich DNA and elucidating how they promote genomic instability.
The current understanding of the mechanism of homology-directed repair is very sophisticated. As participants in the NGEC, the Maizels Lab will harness this understanding to promote correction of genetic defects in situ. Questions it seeks to answer include: Can we increase the efficiency of homology-directed repair? Can we minimize the deleterious consequences of nuclease-targeted therapies?
Key personnel carrying out this research include Luther Davis (postdoctoral fellow), Olivier Humbert (postdoctoral fellow) and Diem-Hang Nguyen-Tran (graduate student).