NGEC Workshop 2011

The fourth annual workshop was held on November 8, 2011, at the UW Medicine South Lake Union campus in Seattle, and it was attended by more than 150 individuals over the course of the day. The workshop featured two keynote addresses by Dr. Carl June (University of Pennsylvania School of Medicine, Philadelphia, PA) and Dr. Nick Grishin (University of Texas Southwestern Medical Center, Dallas, TX), as well as 12 short research presentations and two poster sessions with 44 posters in total.

The complete Abstract Booklet can be downloaded in the Attachment section below.

8:30AM - 8:45AM	Opening remarks
8:45AM - 9:30AM	Keynote I: Nick Grishin (Professor, University of Texas Southwestern Medical Center) Protein remote homology inference and its applications
9:30AM - 9:50AM	Yupeng Wang (Postdoctoral Fellow, Seattle Children's Research Institute) Engineering XID(Btk) site specific I-Anil homing endonucleases for gene repair in hematopoietic stem cells
9:50AM - 10:10AM	Marlene Belfort (Distinguished Professor, University of Albany) A homing endonuclease, stress and mobile DNA
10:10AM - 10:40AM	Coffee break
10:40AM - 11:00AM	Matthew Hirsch (Research Associate, University of North Carolina) Zinc-Finger Nuclease-Mediated Gene Correction using Single AAV Vector Transduction and Enhancement by FDA Approved Drugs
11:00AM - 11:20AM	Trevor Collingwood (Manager Technology Research, Sigma-Aldrich) Targeted Genome Editing Using ssDNA Oligos and Zinc Finger Nucleases
11:20AM - 11:40AM	Fabio Parmeggiani (Postdoctoral Fellow, University of Washington) Binding site grafting in LAGLIDADG homing endonucleases
11:40AM - 12:00PM	Luhan Yang (Graduate Student, Harvard Medical School) Genome editing with Targeted deaminases
12:00PM - 2:00PM	Lunch / Poster Session I
2:00PM - 2:20PM	Frédéric Pâques (CSO, Cellectis) A genome wide study of the efficacy of engineered LAGLIDADG endonucleases
2:20PM - 2:40PM	Richard Frock (Research Fellow, Children's Hospital Boston) Genome-Wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells
2:40PM - 3:00PM	Thomas Gaj (Graduate Student, The Scripps Research Institute) Structure-guided reprogramming of serine recombinase DNA sequence specificity
3:00PM - 3:20PM	Michael Certo (Postdoctoral Fellow, Seattle Children's Research Institute) Coupling site-specific endonucleases with exonucleases substantially increases targeted gene disruption
3:20PM - 3:50PM	Coffee Break
3:50PM - 4:10PM	Martine Aubert (Senior Staff Scientist, Fred Hutchinson Cancer Research Center) Direct targeting and disruption of latent HSV genomes using engineered homing endonucleases
4:10PM - 4:30PM	Matthew Porteus (Associate Professor, Stanford University) Applications of ZFN and TALEN technologies for genome editing
4:30PM - 5:15PM	Keynote II: Carl June (Professor, University of Pennsylvania School of Medicine) Engineering T Cells for CCR5 Deficiency
5:15PM - 7:00PM	Dinner / Poster Session II
7:00PM - 9:00PM	Mingling / Happy Hour

2011 Keynote Speakers

Dr. Carl June
University of Pennsylvania School of Medicine
554 BRB II/III
421 Curie Blvd
Philadelphia, PA 19104
Email: cjune <at> exchange <dot> upenn <dot> edu
Phone: (215) 573-5745
Fax: (215) 573-8590

Carl June is a 1975 graduate of the Naval Academy in Annapolis, and a graduate of Baylor College of Medicine in Houston, 1979. He had graduate training in Immunology at the World Health Organization, Geneva, Switzerland from 1978-79, and post-doctoral training in transplantation biology at the Fred Hutchinson Cancer Research Center in Seattle from 1983 – 1986.

He is board certified in Internal Medicine and Medical Oncology. He was a faculty member in the Departments of Medicine and Cell and Molecular Biology at the Uniformed Services University for the Health Sciences in Bethesda from 1987 to 1998. He is a member of the American Academy of Physicians, and a recipient of the Bristol Myers Squibb Freedom to Discover Award. Since moving to the University of Pennsylvania in 1999 as a tenured Professor of Pathology and Laboratory Medicine, he has established a facility to produce experimental cell based therapeutics. Currently, Dr. June is involved with several clinical trials that are testing various forms of cell based therapies for cancer and HIV infection.

Dr. Nick Grishin
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd
Dallas, TX 75390

Email: grishin <at> chop <dot> swmed <dot> edu
Phone: (214) 645-5952

Nick V. Grishin received his Ph.D. in Molecular Biophysics from the University of Texas Southwestern Medical Center at Dallas and conducted postdoctoral research at the National Center for Biotechnology Information, NLM, NIH, Bethesda MD. He is currently HHMI Investigator and Professor of Biochemistry at the University of Texas Southwestern Medical Center at Dallas.

Dr. Grishin's group uses theoretical methods to understand proteins. They combine sequence and structure analysis with evolutionary considerations to facilitate discoveries of biological significance. Finding and interpreting the most distant evolutionary links between proteins is their unique strength. During the last few years Dr. Grishin's group contributed to evolutionary classification of protein domains, sequence and structure similarity search methods, multiple sequence alignment construction and understanding of sequence-structure-function relationship in protein families.

Attachment	Size
2011 NGEC Workshop Booklet (PDF)	729.82 KB